Afternoon is best time to get your Covid vaccine
December 09, 2021 12:22
In other news, studies on the Covid vaccine, which as we all know, remains ongoing.
Antibody levels are higher when people receive the COVID-19 vaccine in the afternoon as compared to the morning, according to an observational study.
The research, published in the Journal of Biological Rhythms, demonstrates that our internal 24-hour circadian clock regulates many aspects of physiology, including the response to infectious disease and vaccination.
"Our observational study provides proof of concept that time of day affects immune response to SARS-CoV-2 vaccination, findings that may be relevant for optimising the vaccine's efficacy," said study co-senior author Elizabeth Klerman from Massachusetts General Hospital (MGH), US.
The researchers noted that symptoms of some diseases and the action of numerous medications vary by time of day.
The latest study evaluated antibody levels after SARS-CoV-2 vaccination among 2,190 healthcare workers in the UK.
Blood samples were collected from asymptomatic hospital workers at the time of vaccination.
The researchers created a model to investigate the effect on antibody levels based on time of day of vaccination, vaccine type, age, sex, and the number of days post-vaccination.
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They found that antibody responses were higher in general for everyone who was vaccinated later in the day.
The antibody responses were also higher in those who received the Pfizer mRNA vaccine, in women, and in younger people, in addition to the effect of time of day of vaccination, the researchers said.
The study contrasts with earlier studies in elderly men that reported higher anti-influenza titers in the morning.
"The SARS-CoV-2 vaccine and the influenza vaccine have different mechanisms of action from each other, and antibody response may vary greatly depending on whether the immune system recognises the pathogen from earlier infections, such as influenza, or whether it is confronted by a novel virus," said Klerman.
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