Improved HIV antiviral therapies in the offing

April 17, 2016 18:43

Scientists, including one of Indian-origin, have identified a human protein that weakens the immune response to HIV and other viruses, an advance that may help improve antiviral therapies, create viral vaccines and lead to new cancer treatments.

"Our study provides critical insight on a paramount issue in HIV research: Why is the body unable to mount an efficient immune response to HIV to prevent transmission?" said Sumit Chanda, from Sanford-Burnham Prebys Medical Discovery Institute (SBP) in US.

"This research shows that the host protein NLRX1 is responsible - it's required for HIV infection and works by repressing the innate immune response," said Chanda.

The innate immune response works by producing a cascade of signalling chemicals (interferons and cytokines) that trigger cytotoxic T cells to kill pathogens.

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