The shoe was flung at Clifford D May, a US journalist visiting Karachi University on Thursday, the local media reported.
May, who is a Republican and was said to be an active member of the party during George W Bush's administration, was speaking at the Department of International Relations on 'Pakistan's Role in Countering the Challenge of Terrorism' when a student got into action.
Though the shoe was way off the mark, May was whisked away by his security staff.