Cypriot underdogs Anorthosis Famagusta will reach the Champions League last 16 later on Wednesday if they beat Werder Bremen at home and Group B leaders Inter Milan defeat Panathinaikos.
The competition newcomers can seal their shock progression with a game in hand and will be confident after holding the Germans to a 0-0 draw in Bremen in their first group game.
Inter, who drew 3-3 at Anorthosis last time out, need just a point at the San Siro to go through but coach Jose Mourinho is keen to finish top of the group following Saturday's morale-boosting 1-0 Serie A win over Juventus.
Last season's runners-up Chelsea can ensure a place in the knockout stages with a victory at Bordeaux but they will be wary after the 3-1 defeat at AS Roma in their last Group A game.
Roma visit Romania's CFR Cluj, who beat the Italians 2-1 away in their group opener, but neither can progress just yet.
Liverpool will have inspirational midfielder Steven Gerrard back from injury for the visit of Marseille while fellow Group D leaders Atletico Madrid host PSV Eindhoven. Wins would put the English and Spanish sides through while draws for both would also suffice.
Sporting entertain Barcelona in Group C with the two clubs already through to February's last 16. A victory for Barca in Lisbon would make sure they finish top of the group.