Republican Presidential front-runner Donald Trump's Massachusetts campaign headquarters has been vandalised with obscene graffiti and the word 'Nazi' spray-painted on it.

Trump's Massachusetts campaign headquarters in Littleton was discovered vandalised with graffiti and obscenities.

A Littleton police officer in a marked cruiser near the town common was approached by a woman who reported the vandalism, according to a police statement.

The graffiti, scrawled in red and orange paint across the wall and windows of the campaign headquarters on King Street, included a phrase with an expletive and the word 'Nazi', the Boston Globe reported.

'These types of acts are surprising and certainly not representative of the kind of town that Littleton is and the kind of people who live in this community,' Littleton Police Chief Matthew King said in the statement.

Police plans to review surveillance footage in the area, including a nearby gas station, according to the statement.